Journal article
Longitudinal hippocampal volumetric changes in mice following brain infarction
VH Brait, DK Wright, M Nategh, A Oman, WT Syeda, CM Ermine, KR O’Brien, E Werden, L Churilov, LA Johnston, LH Thompson, J Nithianantharajah, KA Jackman, A Brodtmann
Scientific Reports | NATURE PORTFOLIO | Published : 2021
Abstract
Hippocampal atrophy is increasingly described in many neurodegenerative syndromes in humans, including stroke and vascular cognitive impairment. However, the progression of brain volume changes after stroke in rodent models is poorly characterized. We aimed to monitor hippocampal atrophy occurring in mice up to 48-weeks post-stroke. Male C57BL/6J mice were subjected to an intraluminal filament-induced middle cerebral artery occlusion (MCAO). At baseline, 3-days, and 1-, 4-, 12-, 24-, 36- and 48-weeks post-surgery, we measured sensorimotor behavior and hippocampal volumes from T2-weighted MRI scans. Hippocampal volume—both ipsilateral and contralateral—increased over the life-span of sham-ope..
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Grants
Awarded by Centre of Excellence for Electromaterials Science, Australian Research Council
Funding Acknowledgements
These studies were supported by a Dementia Research Team Grant from the National Health and Medical Research Council of Australia (NHMRC; GNT1094974). J.N. was supported by an Australian Research Council Future Fellowship (FT140101327). A.B. was supported by an NHMRC Career Development Fellowship (GNT1045617) and a Heart Foundation Future Leader Fellowship (HFFLF100784). The authors acknowledge the facilities, and the scientific and technical assistance of the National Imaging Facility at the Florey Node.